How CBD Reacts with CB1 and CB2 Receptors

Throughout our body is a system of receptors that is referred to as the endocannabinoid system. These receptors are located all throughout our body in our hearts, lungs, brains, etc. The endocannabinoid system releases our own cannabinoid molecules that are organically made in our body, and these cannabinoids interact with different receptors to produce different results. The main function of the endocannabinoid system is to regulate and maintain bodily homeostasis, while keeping the biological harmony of our body in place in response to environmental changes.

Some of these functions include helping to boost our immune system, allocating nutrients to areas of our body in need and help us increase our overall wellbeing. External cannabinoids interact with our endocannabinoid system as well, which is how CBD and THC produce their effects when ingested into our bodies. Throughout this blog post, we are going to focus on two receptors that are extremely important in our bodies for interacting with CBD, the CB1 and CB2 receptors, and understand how CBD causes these interactions to happen.

Although we have many receptors located throughout our endocannabinoid system, the CB1 and CB2 are the dominant two that control a majority of functioning of the interactions between cannabinoids and our endocannabinoid system. The CB1 and CB2 receptors control different functioning, while some receptors overlap. First, we will look at the CB1 Receptors and understand where its located, what it controls and how CBD works with them to increase our overall functionality.


The CB1 receptors are mostly found throughout our central nervous system. When CBD is introduced into our bodies and begins to interact with these receptors, it acts as an allosteric modulator. This means that it changes the way that the receptor functions without actually activating that receptor at all. Since CBD and THC are both cannabinoids, they both interact with this receptor. The interaction between the two is interesting. The CBD acts as an inhibitor for the CB1 receptor by inhibiting CB1 agonists effects. In this case the CBD acts as the inhibitor to the THC agonist but does not block it.

The two cannabinoids hold different positions in the receptor, so neither one cancels the other, but when ingesting CBD and THC at the same time, users will find that the effects of the THC are negated by the CBD. Things such as memory loss and some psychoactive effects from the THC are two things that are affected by the CBD. Users will not experience the same memory loss, as well as they will have reduced psychoactive effects, helping to make those effects more pleasant. These cannabinoids work in an entourage style and simultaneously interact together.


Although the CB2 receptors can be found in the central nervous system, the majority of them are found in the immune system. Interestingly enough, the CB2 receptors interact with CBD a different way than that of the interactions between CBD and the CB1 receptors. When CBD is introduced into the body, the interaction between the CB2 and the CBD produces a response that makes the CBD act as an inverse agonist.

This means that the CBD ends up occupying the same position as the receptor and produces the opposite effects to the CB2 agonist. With varied levels of concentration, the effects vary widely depending on the levels. The interaction between the CBD and CB2 receptors helps our body to combat things such as swelling, as well as boost our immune system.


The CB1 and CB2 receptors are two different receptors that control different aspects or our body functioning. CBD does miraculous wonders to aid both receptors in different ways. The interaction between CBD and our endocannabinoid system is a very positive one that has many benefits in doing so.

Although CBD can aid our body by working through non-endocannabinoid pathways, the endocannabinoid system still benefits greatly from this compound. Our body was meant to produce its own cannabinoids. Adding external cannabinoids, such as CBD, to our system can help us reach a higher level of body performance and help us regulate our immune system, while maintaining homeostasis.

It is important to understand how CBD can benefit you on a scientific level to really be able to trust and observe the benefits you will receive when taking CBD. Do your research and find products that would benefit you the most while easily fitting into your daily routine to help yourself obtain a happier and healthier life!

FDA Disclaimer: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product. The Federal Food, Drug and Cosmetic Act requires this notice.

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